Source Data Figure 6 .xlsx

c, Quantification of mRNA levels for Sod3 in articular cartilage tissue of rat OA model after vehicle or
BNTA (1.5 mg kg-1) treatment for 4 w (nonparametric test; n = 5 for
each group), SOD3 in human OA
cartilage explants after vehicle or BNTA (0.1 μM) treatment for 3 w (unpaired
two-tailed Student’s t-test; n = 5
for each group), and Sod3 in interleukin
1 beta ( IL1β, 10 ng ml-1)-induced rat OA chondrocytes after BNTA or
vehicle treatment for 6 h (nonparametric test; n = 6 for each group). d, The extracellular and intracellular
SOD activities in rat primary chondrocytes after treated with IL1β (10 ng ml-1)
or BNTA (0.1 μM) for 3 d (one-way ANOVA; n = 6 for each group). e, The ability to produce superoxide
anions of culture media in IL1β (10 ng ml-1)-induced rat OA
chondrocytes incubated with BNTA (0.1 μM) for 2 d and 3 d, which was used to
assess the extracellular superoxide anions content (one-way ANOVA; n = 6 for
each group). g, Quantitative assay of
superoxide anions in IL1β (10 ng ml-1)-induced rat OA chondrocytes
incubated with BNTA (0.1 μM) for 2 d, as assessed with MitoSOX Red staining (one-way
ANOVA; n = 24 for each group). Scale bar, 25 μm. Data are shown as the mean ± standard
deviation (s. d.). *P < 0.05, **P < 0.01, ***P < 0.001.