Structure of the TXNL1-bound proteasome
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https://www.ncbi.nlm.nih.gov/sra/SRP519145
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资源简介：
Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here, we report the cryo-EM structure of thioredoxin-like protein 1 (TXNL1) bound to the 19S regulatory particle of proteasomes via interactions with PSMD1/Rpn2, PSMD4/Rpn10, and PSMD14/Rpn11. Proteasome binding is necessary for the ubiquitin-independent degradation of TXNL1 upon cellular exposure to metal- or metalloid-containing oxidative agents, thereby establishing a structural requirement for the stress-induced degradation of TXNL1. Overall design: RNA sequencing from the indicated cells lines treated with vehicle, arsenite, or hydrogen peroxide
创建时间：
2025-08-28
