Eif2s2 deficiency causes oocyte arrest at the early diplotene stage and apoptosis in mice. Eif2s2 deficiency causes oocyte arrest at the early diplotene stage and apoptosis in mice

Mutations in translation initiation factors are associated with premature ovarian insufficiency. Here, we used signle-cell RNA sequencing method to investigate the effect of Eif2s2 deletion in premeiotic germ-cells on primordial formation. Overall design: Two pooled samples of ovaries from Eif2s2 floxed and cKO mice. Each sample includes 6 ovaries from 3 Eif2s2 floxed and cKO mice.