A bacterial macrolide acts as signalling molecule and rewires the fungal metabolism in the Streptomyces – Aspergillus interaction

Aspergillus nidulans competes in its natural environment with other microorganisms. It has been known that the bacterium Streptomyces rapamycinicus induces the production of Orsellinic acid in A. nidulans and we found that the major trigger of this induction is Polaramycin B produced by S. rapamycinicus. Here we show the transcriptome of A. nidulans following treatment with 0.5µg/ml Polaramycin B after 30 minutes and 3 hours. Overall design: An overnight culture of A. nidulans was treated for 0 hours, 0.5 hours and 3 hours with Polaramycin B (0.5µg/ml ); each experiment is replicated