Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

We show that autochthonous EGFR-driven lung tumors inhibit anti-tumor immunity by activating the PD-1/PD-L1 pathway to suppress T cell function and increase levels of pro-inflammatory cytokines. These findings indicate that EGFR functions as an oncogene through non-cell autonomous mechanisms and raise the possibility that other oncogenes may drive immune escape.