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An unexpected Bromolactamization of Olefinic Amides Using a Three-Component Co-catalyst System

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Figshare2016-02-12 更新2026-04-29 收录
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https://figshare.com/articles/dataset/An_unexpected_Bromolactamization_of_Olefinic_Amides_Using_a_Three_Component_Co_catalyst_System/2087317
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Reaction between (N,N-dimethylamino)­pyridine and isocyanate unexpectedly produced a three-component mixture. By using this mixture as an unprecedented three-component catalyst system, a facile and selective bromolactamization of olefinic amides has been developed. The protocol confers enhanced selectivity of N- over O-cyclization, leading to the formation of a structurally diverse range of lactams including both small and medium ring sizes.
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2016-02-12
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