Crystal structure of Tdp1 catalytic domain in complex with Sigma Aldrich compound CDS010292

Crystal structure of Tdp1 catalytic domain in complex with Sigma Aldrich compound CDS010292 Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-8-(propan-2-yl)quinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 Authors: Lountos, G.T, Zhao, X.Z, Kiselev, E, Tropea, J.E, Needle, D, Burke Jr, T.R, Pommier, Y, Waugh, D.S. Deposit date: 2018-05-25 Release date: 2019-05-29 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.705 Å) Cite: Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening. Nucleic Acids Res., 47, 2019与西格玛奥德里奇（Sigma Aldrich）公司化合物CDS010292结合的Tdp1催化结构域晶体结构 配体描述：1,2-乙二醇、4-羟基-8-异丙基喹啉-3-羧酸、酪氨酰-DNA磷酸二酯酶1（Tyrosyl-DNA phosphodiesterase 1） 作者：Lountos G.T.、Zhao X.Z.、Kiselev E.、Tropea J.E.、Needle D.、Burke Jr. T.R.、Pommier Y.、Waugh D.S. 保藏日期：2018-05-25 发布日期：2019-05-29 最后修改日期：2023-10-11 检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.705埃 引用文献：通过晶体片段组合筛选鉴定配体结合热点及重现酪氨酰-DNA磷酸二酯酶1（TDP1）磷酸识别特征的结构基序。《核酸研究》（Nucleic Acids Res.），第47卷，2019年