Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with Compound 48 (N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide)

Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with Compound 48 (N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide) Descriptor: DIMETHYL SULFOXIDE, N-({(3S)-1-[6-tert-butyl-5-methoxy-8-(2-oxo-1,2-dihydropyridin-3-yl)quinolin-3-yl]pyrrolidin-3-yl}methyl)methanesulfonamide, RNA-DIRECTED RNA POLYMERASE Authors: Harris, S.F, Villasenor, A.G. Deposit date: 2013-08-30 Release date: 2014-05-07 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase. J.Med.Chem., 57, 2014

丙型肝炎病毒聚合酶NS5B 1b型（BK）与化合物48（N-({(3S)-1-[6-叔丁基-5-甲氧基-8-(2-氧代-1,2-二氢吡啶-3-基)喹啉-3-基]吡咯烷-3-基}甲基)甲磺酰胺）的复合物。描述项：二甲基亚砜（dimethyl sulfoxide）、N-({(3S)-1-[6-叔丁基-5-甲氧基-8-(2-氧代-1,2-二氢吡啶-3-基)喹啉-3-基]吡咯烷-3-基}甲基)甲磺酰胺、RNA指导的RNA聚合酶（RNA-directed RNA polymerase）。作者：Harris, S.F.、Villenor, A.G.。提交日期：2013-08-30；发布日期：2014-05-07；最后修改日期：2024-02-28。实验方法：X射线衍射（分辨率2.3 Å）。引用文献：《发现N-[4-[6-叔丁基-5-甲氧基-8-(6-甲氧基-2-氧代-1H-吡啶-3-基)-3-喹啉基]苯基]甲磺酰胺（RG7109）：一种强效丙型肝炎病毒NS5B聚合酶抑制剂》，《药物化学杂志》，第57卷，2014年。