Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

This folder contains data related to the paper: <strong>Disruption of neonatal Purkinje cell function underlies injury-related learning deficits</strong> Aaron Sathyanesan¹*, Panagiotis Kratimenos^1,2,3, and Vittorio Gallo^1,3*<br> ¹ Center for Neuroscience Research and ² Division of Neonatology, Children’s National Research Institute, Children’s National Hospital, Washington DC<br> ³ George Washington University School of Medicine and Health Sciences, Washington DC<br> * Co-corresponding authorship<br> Email: [e-mail] (Vittorio Gallo)<br> [e-mail] (Aaron Sathyanesan) Description of files:<br> 'Figure1.mat' - Contains data related to representative fiber photometry trace in Figure 1D<br> 't' - total time of recording (in seconds)<br> 'dFF_480' - GCaMP6f dFF trace<br> 'dFF_405' - Isosbestic control trace<br> 'USonly', 'CSonly', 'Paired', and 'trials' - categorized time-marked events 'Figure2_and_SIAppendix_FiguresS4-S6.mat' - Contains data related to Figure 2A-D, and SI Appendix Figures S4-S6<br> 'FP_1' - structural array containing relevant data<br> 'FP_1.condition' - 'Nx' or 'Hx' (Figure 2C-D)<br> 'FP_1.day' - learning session 1, 2, or 3 (Figure 2C-D)<br> 'FP_1.zCSUS' - mean z-score dF/F in CS-US window for paired learning trials (Figure 2G)<br> 'FP_1.zdFF' - all z-score dF/F traces (Figure 2C-D)<br> 'FP_1.CSUS_t' - time vector with t = 0 as C.S. onset (Figure 2C-D)<br> 'FP_1.rep_cond' - 'Nx' or 'Hx' for representative data (Figure 2A-B)<br> 'FP_1.rep_day' - learning session 1, 2, or 3 (Figure 2A-B)<br> 'FP_1.rep_dFF' - normalized GCaMP6f dF/F for (Figure 2A-B)<br> 'FP_1.trialduration' - trial durations for all trials (SI Appendix Figure S4)<br> 'FP_1.missteptime' - missteptime for all trials (SI Appendix Figure S5)<br> 'FP_1.velocity' - velocity for all trials (SI Appendix Figure S6)<br> 'FP_1.shortsteptime' - short steptime for trials (SI Appendix Figure S4)<br> 'FP_1.shortmissteptime' - short missteptime for all trials (SI Appendix Figure S5)<br> 'FP_1.longsteptime' - long steptime for trials (SI Appendix Figure S4)<br> 'FP_1.longmissteptime' - long missteptime for all trials (SI Appendix Figure S5)<br> 'FP_1.zPost' - z-scored post-perturbation steptime (Figure 2G) 'Figure3.mat' - Contains data related to Figure 3C<br> 'FP_2' - structural array containing relevant data<br> 'FP_2.condition' - 'saline' or 'CNO'<br> 'FP_2.day' - learning session 1, 2, or 3<br> 'FP_2.zdFF_DRD' - all z-score dF/F traces<br> 'FP_2.CSUS_tmod' - time vector with t = 0 as C.S. onset 'SIAppendix_FigureS2.mat' - Contains data related to SI Appendix Figure S2b-c<br> 'Nx' - structural array containing relevant data to Nx animal<br> 'Hx' - structural array containing relevant data to Hx animal <br> In both Nx and Hx:<br> 'trial_rep' - representative trial event mark<br> 't_rep' - time<br> 'air_rep' - air onset event mark<br> 'dFF_480_rep' - GCaMP6f dF/F signal 'SIAppendix_FigureS3.mat' - Contains data related to SI Appendix Figure S3a and d<br> 'FP_US' - structural array containing relevant data to US-only trials<br> 'FP_US.condition_US' - 'Nx' or 'Hx'<br> 'FP_US.zUStrialsonly - z dF/F traces in US only trials<br> 'FP_US.CSUS_tmod - time with respect to t = 0 as U.S. onset<br> 'FP_CS' - structural array containing relevant data to CS-only trials<br> 'FP_CS.condition_CS' - 'Nx' or 'Hx'<br> 'FP_CS.zCStrialsonly - z dF/F traces in CS only trials<br> 'FP_CS.CSUS_tmod - time with respect to t = 0 as C.S. onset 'Figure 2E data.pdf' - Contains data related to Figure 2E 'Figure 2F data.pdf' - Contains data related to Figure 2F 'Figure 2H data.pdf' - Contains data related to Figure 2H 'Figure 3D data.pdf' - Contains data related to Figure 3D 'SIAppendix Figure S3 data.pdf' - Contains data related to SI Appendix Figure S3 'SIAppendix Figure S7 data.pdf' - Contains data related to SI Appendix Figure S7 'SIAppendix Figure S8 data.pdf' - Contains data related to SI Appendix Figure S8 'SIAppendix Figure S9 data.pdf' - Contains data related to SI Appendix Figure S9