Crystal structure of MurA from Clostridium difficile, mutation C116D, n the presence of UDP-N-acetylmuramic acid

Crystal structure of MurA from Clostridium difficile, mutation C116D, n the presence of UDP-N-acetylmuramic acid Descriptor: (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, 1,2-ETHANEDIOL, UDP-N-acetylglucosamine 1-carboxyvinyltransferase Authors: Dopkins, B.J, Call, C.J, Thoden, J.B, Holden, H.M. Deposit date: 2019-08-01 Release date: 2019-11-27 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Crystal structure of MurA from Clostridium difficile, mutation C116D, n the presence of UDP-N-acetylmuramic acid To Be Published

艰难梭菌（Clostridium difficile）MurA蛋白的晶体结构：该蛋白为C116D突变体，实验体系中添加UDP-N-乙酰胞壁酸（UDP-N-acetylmuramic acid）。
配体描述：(2R)-2-{[(2R,3R,4R,5S,6R)-3-(乙酰氨基)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-3,4-二羟基四氢呋喃-2-基]甲氧基}(羟基)磷酰基]氧基}(羟基)磷酰基]氧基}-5-羟基-6-(羟甲基)四氢-2H-吡喃-4-基]氧基}丙酸、1,2-乙二醇（1,2-ETHANEDIOL）、UDP-N-乙酰葡糖胺1-羧基乙烯基转移酶（UDP-N-acetylglucosamine 1-carboxyvinyltransferase）
作者：Dopkins, B.J.、Call, C.J.、Thoden, J.B.、Holden, H.M.
沉积日期：2019-08-01
发布日期：2019-11-27
最后修改日期：2023-10-11
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.65埃（1.65 Å）
引用说明：艰难梭菌MurA蛋白C116D突变体在UDP-N-乙酰胞壁酸存在下的晶体结构，待发表