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Synchronized HES7 Oscillation In Human Embryonic Stem Cell-Derived Presomitic Mesoderm

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干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=ac4db8a6319528f59f110d5718ac8c81
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资源简介:
Little is known about human segmentation clock during somitogenesis. Human embryonic stem (ES) cell differentiation towards PSM and somite cells provide a window of opportunity to probe for the dynamics of oscillatory gene expression. Using high temporal RNA-seq, we captured a transcriptional signature highly reminiscent of segmentation clock during somite differentiation. Our study provides a novel in vitro system to model human segmentation clock that is otherwise inaccessible during development.
提供机构:
Morgridge Institute for Research
创建时间:
2022-02-20
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