Astrocyte-Derived Clusterin Disrupts Glial Physiology to Obstruct Remyelination in Mouse Models of Demyelinating Diseases

NIAID Data Ecosystem2026-05-02 收录

脱髓鞘疾病病理机制

胶质细胞功能研究

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1147797 数据链接链接失效反馈

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This study delves into the pathogenic role of astrocytic CLU in a murine model of demyelinating lesions.

创建时间：

2024-08-13

The RNA sequencing of brain after microglial depletion and repopulation. The RNA sequencing of brain after microglial depletion and repopulation

胶质细胞功能研究

神经免疫转录组学

The RNA sequencing of brain after microglial depletion and repopulation Overall design: Brain mRNA profiles of adult wild type C57BL/6J mice, after treatments of PLX5622, control diet (CD), LPS, vehic

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Alzheimer’s disease (AD) is the most prevalent cause of dementia, but still no effective treatment exists. Microglia have been implicated in AD pathogenesis, but their role is still matter of debate.

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An investigation into the effects of ATV:Trem2 on AD model mice using scRNA-seq

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WT hTfR-KI mice and APP/SAA hTfR-KI mice were treated with one of: Isotype control ATV, naked 4D9 (activating Trem2 Ab), or ATV:4D9. Drugs were delivered IV. After 24 hours, mice were sacrificed, and

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We identified enrichment of a disease-enhancing, proinflammatory subpopulation of microglia in human AD patient brains with the R47H-TREM2 mutation, and uncovered that enhanced Akt signaling in microg

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Generation of human microglia-like cells to study neurological disease. Homo sapiens

神经退行性疾病模型

胶质细胞功能研究

Microglia play important roles in developmental and homeostatic brain function, and influence the establishment and progression of many neurological disorders. Here, we demonstrate that renewable huma

NIAID Data Ecosystem50

Astrocyte-Derived Clusterin Disrupts Glial Physiology to Obstruct Remyelination in Mouse Models of Demyelinating Diseases

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