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Important gene events during transformation of benign cells into tumor cells
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2021-10-14
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Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST. Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST
Plexiform neurofibromas (PN) are benign nerve sheath Schwann cell tumors, common in patients with neurofibromatosis type 1 (NF1), that are characterized by biallelic mutations in the NF1 tumor suppres
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Table_2_A Candidate Prognostic Biomarker Complement Factor I Promotes Malignant Progression in Glioma.DOCX
Objectives: Glioma is the most common and aggressive type of primary central nervous system (CNS) tumor in adults and is associated with substantial mortality rates. The aim of our study was to evalua
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Cell-type Specific Regulation of Gene Expression by Simian Virus 40 T antigens
SV40 transforms cells through the action of two oncoproteins, large T antigen and small t antigen. Small t antigen targets phosphatase PP2A, while large T antigen stimulates cell proliferation and sur
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Studies of driver genes in prostate cancer
Important gene events during transformation of benign cells into tumor cells
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Oncogene-induced senescence
This experiment was designed to study oncogene-induced senescence (OIS). To this end we generated a series of cell lines derived from normal human diploid fibroblasts IMR90 forced to express the catal
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