CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response

CD44 is a transmembrane adhesion molecule and the major receptor for hyaluronan. The function of CD44 has been implicated in numerous biological processes. Our study finds that zebrafish CD44a variants function as positive regulators in antibacterial response. In order to reveal the possible antibacterial mechanism of CD44a, the wild-type and CD44a-/--14del zebrafish larvaes infected with E. piscicida collected at 24 and 48 hpi were used for transcriptome sequencing. Our data demonstrate that zebrafish CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Overall design: The hatched larvae (4 dpf) from wild-type and CD44a mutants (CD44a-/--14del) were infected with E. piscicida, the infection was performed in triplicate with a parallel group with 50 fish per group. At 24hpi and 48hpi; the larvae in each group was collected for cDNA Library Construction and Illumina Deep Sequencing.