Novel Alterations in Chromatin Structure during Aging Reveal Cell-Specific Differential Expression of SUMO Proteins

We investigated the chromatin accessibility of primary human adipose-derived stem cells (ASCs) and fibroblasts during chronological aging using ATAC-seq technology. our data suggest a significant role for nucleosome positioning in sumoylation pathway regulation in response to stress during aging of adult stem cells. Compared chromatin accessiblity and promoter nucleosome positioning of human ASCs and fibroblasts during aging