Mutations of the FOXP2 gene cause a severe speech and language disorder, providing a molecular window into the neurobiology of language. Individuals with FOXP2 mutations have structural and functional
RNA-sequencing analysis of E17.5 DA from Prdm6f/f; SM22-Cre mice and wildtype littermates identified contractile proteins such as Tagln and Myh11 as the most downregulated genes in the DA of Prdm6f/f;
In our original grant we proposed to use the NR3B-null mouse model to study the role of NR3B subunit in motor neuron function. We have now successfully generated NR3B null mice. Interestingly, NR3B-nu