Fitting settings used for model development with ITSB and the resulting parameters.

In bold the selected endocarditis model, based on the AIC and ΣWSS/df as close to zero as possible. AIC = Akaike Information criterion, CLm = metabolic or non-renal clearance, fr = renal gentamicin clearance as a fraction of creatinine clearance, FPB = fixed population Bayesian, ICU = Intensive Care Unit, Vd = volume of distribution, ΣWSS/df = sum of the weighted sum of squares of the concentrations and parameters divided by the degrees of freedom. (S2 Data).