Genome-wide Dppa4 binding in E14 mESC, 3T3, and P19 cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=cfd82344129992e369ff075c606ff1a4
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DPPA4 is a DNA-associated factor that is highly and selectively expressed in embryonic stem cells. DPPA4 expression is strikingly downregulated upon loss of pluripotency, but is reactivated in a number of cancer cell types. It has recently been identified as an oncogene and shown to promote cell proliferation and anchorage independent growth; Dppa4-transformed cells can form tumors in vivo in mice. DPPA4 has been shown to associate with active chromatin and histone H3, but the global binding dynamics of DPPA4 are unknown. Additionally, only several DPPA4 gene targets are known. To better understand the role of DPPA4 in embryonic stem cell pluripotency and oncogenesis, we performed ChIP-Seq in E14 mouse embryonic stem cells (mESC), 3T3 cells ectopically expressing DPPA4, and P19 embryonic carcinoma cells.
提供机构：
University of California Davis
创建时间：
2022-02-20
