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DNA-Protein Crosslink sequencing (DPC-seq) in RPE-1 cells treated with formaldehyde

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NIAID Data Ecosystem2026-05-02 收录
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Covalent DNA-protein crosslinks (DPC) are toxic DNA lesions that require repair by global-genome and replication-coupled pathways. How cells respond when RNA polymerases stall at DPCs during transcription is unknown. DPC-seq is new method for the genome-wide mapping of covalent DNA-protein adducts.

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2024-09-06
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