Effect of depletion of FABP4 in mice intestinal epithelial cells on gene expression. Effect of depletion of FABP4 in mice intestinal epithelial cells on gene expression

To investigate the function of FABP4 in the intestinal in vitro cultured organoids,FABP4, which located in crypt lyszyme+ Paneth cells can regulate the expression of defensins, especially HFD-mediated downregulation of defensin in Paneth cells will provide insights into factor(s) underlying modern diseases. We then performed gene expression profiling analysis using data obtained from RNA-seq of FABP4fl/flpvillinCreT (FABP4KO) mice and FABP4fl/fl (WT)mice in vitro cultured intestinal organoids. Overall design: Comparative gene expression profiling analysis of RNA-seq data for FABP4fl/flpvillinCreT (FABP4KO) mice and FABP4fl/fl (WT)mice in vitro cultured intestinal organoids.