Crystal structure of the human METTL3-METTL14 complex with compound UOZ091

Crystal structure of the human METTL3-METTL14 complex with compound UOZ091 Descriptor: 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-2-oxidanyl-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Huang, D, Caflisch, A. Deposit date: 2021-05-03 Release date: 2021-10-20 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3 Acs Bio Med Chem Au, 2023人源METTL3-METTL14复合物与化合物UOZ091的共晶结构。组分描述：4-[[(3S)-3-环丙基-2-氮杂螺[3.3]庚烷-2-基]甲基]-2-羟基-N-[[(3R)-3-羟基-1-[6-[(苯甲基)氨基]嘧啶-4-基]哌啶-3-基]甲基]苯甲酰胺、乙酸根离子、N6-腺苷甲基转移酶催化亚基等。作者：Bedi, R.K.、Huang, D.、Caflisch, A.。沉积日期：2021-05-03；发布日期：2021-10-20；最后修改日期：2024-10-23。实验方法：X射线衍射（分辨率1.9 Å）。引用文献：《m6A RNA修饰酶METTL3抑制剂的结构导向设计》，发表于*Acs Bio Med Chem Au*，2023年