Association between metabolites replicated in the univariable analysis and CHD, adjusting for main cardiovascular risk factors, meta-analysis results from ULSAM and TwinGene (N = 2,698).

* Values are from random effect meta-analysis of Cox proportional hazards analyses for a SD increment of the metabolic feature adjusted by age, sex (only in TwinGene), systolic blood pressure, body mass index, current smoker, antihypertensive treatment, LDL cholesterol, HDL cholesterol, log-triglycerides and diabetes at baseline. †Significant interaction with age; we modeled an interaction between age and LysoPC 18∶2 and included the estimates for individuals older than 70 in the meta-analysis. Metabolites in bold showed P-value<0.05 for association with CHD. Association between metabolites replicated in the univariable analysis and CHD, adjusting for main cardiovascular risk factors, meta-analysis results from ULSAM and TwinGene (N = 2,698).