PDI-TCR reveals the dynamics and phenotypes of CD4 T cells in tuberculosis

NIAID Data Ecosystem2026-05-10 收录

结核病T细胞免疫

TCR测序分析

数据链接：

https://immport.org/shared/study/SDY3090 数据链接链接失效反馈

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资源简介：

We developed the Peptide-Driven Identification of TCRs (PDI-TCR) assay, which combines in vitro cell expansion with peptide pools, bulk TCR sequencing, and statistical analysis to identify antigen-specific TCRs from human blood

创建时间：

2026-03-26

TCR repertoire analysis reveals increased host CTL diversity induced by CD8a ALN-1. TCR repertoire analysis reveals increased host CTL diversity induced by CD8a ALN-1

TCR测序分析

肿瘤免疫应答

Collectively, these data present evidence that the antitumor response mediated by CD8a ALN-1 correlates with clonal expansion and increased TCR repertoire diversity in the TDLN and the tumor tissue, i

NIAID Data Ecosystem110

TCR-seq to study features of the transcriptome and TCR repertoire of a stably persisting population of regulatory T cells generated in mice with autoimmune inflammation by conversion from Treg "wannabes"

T细胞免疫调节

TCR测序分析

The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of the transcription factor Foxp3. Foxp3 loss-of-function or induced ablation of Treg cells results in

NIAID Data Ecosystem50

Clonal Analysis of the T-Cell Response to In Vivo Expressed Mycobacterium tuberculosis Protein Rv2034, Using a CD154 Expression Based T-Cell Cloning Method

结核病T细胞免疫

疫苗候选抗原鉴定

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of death worldwide. A better understanding of the role of CD4+ and CD8+ T cells, which are both important to TB p

NIAID Data Ecosystem20

TCR repertoire sequencing analysis using RNA on fibrotic livers. TCR repertoire sequencing analysis using RNA on fibrotic livers

肝纤维化免疫治疗

TCR测序分析

Fibrosis is the final path of nearly every form of chronic disease and accounts for up to 45% of all deaths in the developed world. However, antifibrotic therapies that target fibrogenic cells are lac

NIAID Data Ecosystem80

Interferons limit autoantigen-specific CD8+ T-cell expansion in the non-obese diabetic mouse

糖尿病免疫机制

TCR测序分析

Interferon gamma (IFNg) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNg have been disappointing in reducing disease. We characterised isl

NIAID Data Ecosystem40

PDI-TCR reveals the dynamics and phenotypes of CD4 T cells in tuberculosis

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