A Small Molecule Activator of the TET2 Tumor Suppressor
收藏NIAID Data Ecosystem2026-03-14 收录
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TET2 protein is a dioxygenase that oxidizes 5-methylcytosine and is responsible for DNA demethylation. We found that a small molecule drug (3FM-dC) activates the enzyme activity of TET2. The sequencing data suggest that 3FM-dC induced global changes in DNA hydroxymethylation and gene expression. To determine the effects of 3FM-dC on global gene expression, we performed RNA-seq on control and 3FM-dC treated K-562 cells.
创建时间：
2022-10-21
