Predicted and observed experimental outcomes of the expression of p97 and p97R155C in AX2 wild-type and ATG9KO cells.

The table summarizes the predicted changes based on the model of p97 and ATG9 interaction and mutual inhibition as illustrated in Fig. 9. Experimental results in black; model validity in green; “no” and “no” with uppercase “1)”, see Discussion section; “ref value”, changes were separately compared to wild-type and ATG9KO backgrounds; ↑, ↓, →, increase, decrease or no change with respect to the reference value. Inverse, inverted mutation specific effect. Rescue, partial or full rescue of the ATG9KO phenotype.