Evogliptin increased energy expenditure unlike exenatide.

HF-DIO mice were treated with exenatide (30 μg kg-1, once daily, s.c.) or evogliptin at 0.081% (w/w) for 2 weeks. Metabolic parameters were measured using an indirect calorimetry system; (A) Oxygen consumption (VO2) and carbon dioxide production (VCO2), (B) mean energy expenditure (EE), (C) respiratory quotient (Rq), and (D) a plot of individual data of total mean EE vs. (lean mass + 0.2 × fat mass) as a covariate (n = 8/group). #, P < 0.05 vs. lean control and *, P < 0.05 vs. HF-DIO control by one-way ANOVA.