The Susceptibility of Escherichia coli to Antibiotics and Medicinal Plant Extracts Used in Folklore Medicine in Ika North Local Government Area of Delta State Nigeria

Medicinal plants are a potential source of new drugs like antimicrobials. The need for new antimicrobials is necessitated by the fact that multi-drug resistance by bacteria is now a common phenomena. The medicinal plants used to treat infectious diseases in Delta were investigated as potential replacement for antibiotics used locally for the treatment of Staph infections. The ethnobotanical use of the plants used is shown in tables 1a and b. This was got from different literature and also by interviewing locals. Polar compounds were extracted with ethanol and methanol while non polar compounds were got with chloroform and n-hexane and are shown in figures 1, 2, 3, 4.These compounds and also aqueous extracts were got from the fifteen medicinal plants used were tested on the growth of the test organism Escherichia coli. the susceptibility of the test organism to the various extracts was accessed using the criteria set by ACCLS, 2012. The data indicates that while the test organism was not susceptible to any of the antibiotics tested but instead showed intermediate susceptibility. The data show that the test organism was susceptible to some of the plants tested and as such could be investigated further as potential sources of new drugs for the treatment of staph infections.

药用植物是新型药物如抗菌素的潜在来源。鉴于细菌的多药耐药性已成为一种普遍现象，开发新型抗菌素的需求日益迫切。在Delta地区，用于治疗感染性疾病的药用植物被研究作为当地用于治疗金黄色葡萄球菌感染的抗生素的潜在替代品。表格1a和b展示了这些植物的民族植物学用途，该信息来源于不同文献以及当地居民的访谈。极性化合物通过乙醇和甲醇提取，而非极性化合物则通过氯仿和正己烷提取，相关结果展示于图1、2、3、4中。这些化合物以及水提取物均来源于所使用的十五种药用植物，并对其对测试菌株大肠杆菌的生长影响进行了测试。测试菌株对各种提取物的敏感性评估参照ACCLS，2012年设定的标准进行。数据显示，测试菌株对所测试的任何抗生素均不敏感，反而表现出中等敏感性。数据表明，测试菌株对某些测试的植物显示出敏感性，因此这些植物可作为治疗金黄色葡萄球菌感染的新药来源进行进一步研究。