Replication Study Results and Combined Meta-Analysis.

Combined association results for 12 SNPs representing 5 independent regions that reached genome-wide significance in the original GWAS. The combined effect estimates (per allele odds ratios) in the replication cohorts were all direction-consistent with the ones in the original GWAS cohorts. Significant heterogeneity was noted only for the second HLA locus represented by rs9357155 and rs2071543.Q-test: P-value for the Cochrane's Q statistic for heterogeneity, NS: heterogeneity test not significant,*heterogeneity P**heterogeneity PI2: Heterogeneity Index (0–100%), where 75% to high level of heterogeneity;OR: Additive (per-allele) Odds Ratio;#Han and Eskin random effects model.