Effects of TbKHC1 on <i>T. brucei</i> parasitaemia.

WT and TbKHC1 KO parasitaemias were monitored in various mice and conditions: (A) WT mice treated with L-NAME or D-NAME; (B) iNOS KO and WT mice; (C,D) myeloid cell Arg1 KO mice (KO1 = LysMcreArg1-/lox; KO2 = Tie2creArg1-/lox) and controls (Arg1lox/lox); (E,F) WT mice treated with L-ornithine, D-mannose or D-galactose; (G) MMR KO and WT mice; (H) SIGN-R1 KO and control (Ctrl) mice. Data are means ± SEM of 4 individual mice of one representative from 3 independent experiments. * p<0.05 comparing D-NAME and L-NAME treated mice (A) or WT and iNOS KO mice (B) infected with WT parasites; ∇ p<0.05 comparing Arg1lox/lox and LysMcreArg1-/lox or Tie2creArg1-/lox mice infected with WT parasites; # p<0.05 comparing L-ornithine treated and non treated mice infected with TbKHC1 KO parasites; ¥ p<0.05 comparing D-mannose and D-galactose-treated mice infected with WT parasites; £ p<0.05 comparing SIGN-R1 KO and control mice infected with WT parasites.