LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S)

LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S) Descriptor: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate Authors: Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. Deposit date: 2014-08-05 Release date: 2014-09-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014LSD1(KDM1A)-CoREST与1-甲基反苯环丙胺(1R,2S)的复合物 描述符：赖氨酸特异性组蛋白去甲基化酶1A、REST共阻遏因子1、[(2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基]甲基 (2R,3S,4S)-2,3,4-三羟基-5-[(4aS)-4a-[(1S,3E)-3-亚氨基-1-苯基丁基]-7,8-二甲基-2,4-二氧代-3,4,4a,5-四氢苯并[g]蝶啶-10(2H)-基]戊基二氢二磷酸酯 作者：Vianello, P、Botrugno, O、Cappa, A、Ciossani, G、Dessanti, P、Mai, A、Mattevi, A、Meroni, G、Minucci, S、Thaler, F、Tortorici, M、Trifiro, P、Valente, S、Villa, M、Varasi, M、Mercurio, C 存档日期：2014-08-05 发布日期：2014-09-10 最后修改日期：2024-01-10 实验方法：X射线衍射（分辨率2.9 Å） 引用文献：《1-取代环丙胺衍生物的合成、生物活性及作用机制研究：一类新型组蛋白去甲基化酶Kdm1A不可逆抑制剂》，Eur.J.Med.Chem., 86C, 2014