glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate

EARS2 (mitochondrial glutamyl tRNA synthetase) catalyzes the reaction of glutamate, mitochondrial tRNA(Glu), and ATP to form Glu-tRNA(Glu), AMP, and pyrophosphate. The EARS2 gene has been identified by computational analysis of the human genome sequence; its function has been inferred from those of the biochemically characterized mitochondrial aspartyl and tyrosyl tRNA synthetases (Bonnefond et al. 2005).

EARS2（线粒体谷氨酰tRNA合成酶）催化谷氨酸、线粒体tRNA(Glu)和ATP的反应，生成谷氨酰tRNA(Glu)、AMP和焦磷酸。EARS2基因通过对人基因组序列的计算分析而被鉴定；其功能推断自已生化特性化的线粒体天冬酰和酪氨酰tRNA合成酶的研究（Bonnefond等，2005年）。