Single cell evaluation of the developing pancreatic tumor microenvironment and its response to chronic jetlag

Chronic jetlag is a risk factor for cancer development, we subjected mice that develop pancreatic cancer to normal or chronic jetlag conditions and used scRNAseq to evaluate the developing tumor microenvironment Overall design: 1 pololed Male/Female from 5 and 9 month old KrasG12D Pdx1-Cre pancreata subjected to either normal circadian or chonic jetlag conditions were compared with scRNAseq