Whole Genome Sequencing of a cohort of Mapuche-Huilliche individuals from Southern Chile

Whole human genome sequencing initiatives provide a compendium of human genetic variants that help us understand human and population history and the basis of genetic diseases. Current data mostly focuses on Old World populations and information on the genomic structure of Native Americans, especially those from the Southern Cone is scant. We present here a high quality complete genome sequence of a cohort of 11 Mapuche-Huilliche individuals (HUI) from Southern Chile. This cohort represents a marginally admixed Native American population from the Southern Cone that contributes to understanding the genetic structure of the contemporary admixed Chilean Latino population harboring a significant Mapuche-Huilliche genetic component. The high quality HUI genomes reported here should become a resource to help the international community in future genetic studies in modern Native American or admixed Latin populations with Native American ancestry.