An Interferon-stimulated long non-coding RNA USP30-AS1 regulates antiviral immunity in influenza virus infection

Long non-coding RNAs (lncRNAs) are groups of regulators that modulate or control biological processes of importance, including inflammation and antiviral immunity. However, what we know about lncRNAs in influenza A virus (IAV) infection induced immune response is limited. By performing a series of virological and biological assays together with bioinformatical approaches, we discovered an interferon-stimulated lncRNA USP30-AS1 as a vital immune regulator that engages inflammatory response in IAV infection.