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Crystal structure of GH9 (K101P, K103N, V108I) HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 5i3

NIAID Data Ecosystem2026-05-02 收录

HIV-1逆转录酶

非核苷类抑制剂结合模式

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Crystal structure of GH9 (K101P, K103N, V108I) HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 5i3

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创建时间：

2025-06-11

HIV-1逆转录酶

非核苷类抑制剂复合物

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION Descriptor: (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE,

Protein Data Bank Japan2024-02-07 更新70

Structural Basis of HIV‑1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY‑1

HIV-1逆转录酶

艾滋病药物设计

HIV-1 reverse transcriptase (RT) is an essential enzyme, targeting half of approved anti-AIDS drugs. While nucleoside RT inhibitors (NRTIs) are DNA chain terminators, the nucleotide-competing RT inhib

NIAID Data Ecosystem50

Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode

HIV-1逆转录酶

RNA水解

Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode

NIAID Data Ecosystem10

Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms

结构生物学

HIV-1逆转录酶

Crystal structure of HIV-1 reverse transcriptase covalently tethered to DNA template-primer solved to 2.8 angstroms Descriptor: 5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*A

Protein Data Bank Japan2024-11-20 更新50

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-264

HIV-1逆转录酶

抑制剂设计

HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-264 Descriptor: (S)-2-(3-(6-amino-9H-purin-9-yl)propoxy)-3-phosphonopropanoic acid, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*

Protein Data Bank Japan2024-01-31 更新20

Crystal structure of GH9 (K101P, K103N, V108I) HIV-1 reverse transcriptase in complex with non-nucleoside inhibitor 5i3

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