Risk ratios of FLG variants interacting with allergic sensitization and eczema on the subsequent occurrence of eczema (Eczema model) and allergic sensitization (Allergic sensitization model).

RR: Risk ratio; CI: Confidence interval.*This log-binomial model tests whether allergic sensitization, FLG variants and their interaction predict the transition of eczema (change is disease status from eczema-free to eczema in three consecutive study assessments). Also, gender and age at follow-up were included in the model as covariates.†This log-binomial model tests whether eczema, FLG variants and their interaction predict the transition of allergic sensitization (change in status from having negative skin prick test to positive skin prick test in three consecutive study assessments). Also, gender and age at follow-up were included in the model as covariates.‡Refers to the percent of children who were eczema-free or non-atopic at the initial assessment of the transition period and developed eczema or allergic sensitization at the second assessment of the same transition period.¶RR of combined effect of allergic sensitization and FLG variants on development of eczema was calculated as: RR = exp(−0.36+0.04+1.39).$RR of combined effect of eczema and FLG variants on development of allergic sensitization was calculated as: RR = exp(0.15+0.1+0.31).