Additional file 1: of Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China

Summary information for mutational spectrum, targeted sequencing genes, amplification primers, antibodies, clinical features and haplotype analysis. Table S1. A reanalysis of the mutational spectrum in 41 reported studies exhibiting HSP in China. Table S2. HSP related genes included in the targeted sequencing panel. Table S3. Primers for amplification in the experimental procedures. Table S4. List of antibodies, related to immunocytochemistry (ICH) and western blotting (WB) in the experimental procedures. Table S5. Summary of clinical features of SPG4 patients in China (n=273). Table S6. Summary of clinical features of SPG11 patients in China (n=52). Table S7. Summary of clinical features of SPG5 patients in China (n=28). Table S8. Haplotypes of tagSNPs linkage to CYP7B1 gene in the 16 unrelated SPG5 families. (XLSX 69 kb)