Genetic modifiers of Duchenne muscular dystrophy in Chinese patients-Supplementary Material

We genotyped LTBP4 haplotypes and the SPP1 promoter SNPs rs28357094,
rs11730582, and rs17524488 in 326 patients registered in the neuromuscular
database of The First Affiliated Hospital of Sun Yat-sen University.
Kaplan-Meier curves and log-rank tests were used to estimate and compare median
age at loss of ambulation, while Cox proportional hazard regression models were
used as to analyze the effects of glucocorticoids treatments,
DMD genotype, and SPP1/LTBP4
SNPs on loss of ambulation.This
study was approved by the ICE for Clinical Research and Animal Trial at First
Affiliated Hospital of Sun Yat-sen University, and informed consent was
obtained from each included patient prior to the survey.