PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL095 in complex with MAP kinase p38-alpha

PanDDA analysis group deposition Form1 MAP kinase p38-alpha -- Fragment KCL095 in complex with MAP kinase p38-alpha Descriptor: 3-(4-chlorophenyl)imidazole-2,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-04 Release date: 2020-07-22 Last modified: 2026-02-18 Method: X-RAY DIFFRACTION (1.767 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

PanDDA分析小组提交的表单1：丝裂原活化蛋白激酶p38-α（MAP kinase p38-alpha）——与丝裂原活化蛋白激酶p38-α结合的片段KCL095。组成成分：3-(4-氯苯基)咪唑-2,4-二酮、氯离子、二甲基亚砜等。作者：De Nicola G.F.、Nichols C.E.。提交日期：2020-03-04；发布日期：2020-07-22；最后修改日期：2026-02-18。检测方法：X射线衍射（1.767埃）。引用文献：《挖掘PDB以寻找可通过X射线晶体学结合片段筛选系统设计蛋白质-蛋白质抑制剂的可行案例：以IL1β-IL1R与p38α-TAB1复合物为例的两个测试案例》，《药物化学杂志》（J.Med.Chem.），63卷，2020年。