Intracranial self-stimulation regulates gene expression in rat hippocampus

Rats were implanted with a monopolar stainless steel electrode aimed at the lateral hypothalamus in the right hemisphere. Hippocampal gene expression was analyzed 4.5h post treatment comparing rats subjected to acute self-stimulation (2500 stimulation trains; ICSS group) with sham-operated rats (with electrode placement but placed in the ICSS without stimulation during 40 min.; Sham group).向大鼠右侧大脑半球的下丘脑外侧区植入单极不锈钢电极。于处理后4.5小时分析海马基因表达水平，对比接受急性自我刺激的大鼠与假手术组大鼠的表达差异：急性自我刺激组大鼠共接受2500次刺激序列，即颅内自我刺激（intracranial self-stimulation，ICSS）组；假手术组大鼠仅完成电极植入操作，在40分钟时长内被置于ICSS装置中但未接受刺激。