Metadata record for the manuscript: Inflation of Tumor Mutation Burden by Tumor-Only Sequencing in Under-Represented Groups

Summary This metadata record provides details of the data supporting the claims of the related manuscript: “Inflation of Tumor Mutation Burden by Tumor-Only Sequencing in Under-Represented Groups ”. The related study investigated the impact of minority group representation in public germline variant databases and hypothesised that tumour mutational burden (TMB) would be more greatly inflated in underrepresented groups. Type of data: exome sequencing data of tumor (CD138+ bone marrows) and patient-paired germline samples, clinical characteristics of patients Subject of data: Homo sapiens Sample size: 701 patients Population characteristics: 575 self-reported White patients and 126 self-reported Black patients Data access The exome sequencing data of tumour (CD138+ bone marrows) and patient-paired germline samples can be obtained by controlled access from dbGAP under accession https://identifiers.org/dbgap:phs000748. The self-reported race and other clinical characters of the patients can be accessed from the Multiple Myeloma Research Foundation Researcher Gateway (https://research.themmrf.org/). Additionally, the data underlying the figures, table and supplementary file of the related article, as well as Supplementary File 1 (Excel spreadsheet) are shared as part of this figshare record in the files ‘Supporting_Data.xlsx’ and ‘Supplemental File 1.xlsx’. Corresponding author(s) for this study Aaron S. Mansfield, MD, Division of Medical Oncology, Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905 ([e-mail]) 507-266-9160.