Lysyl Hydroxylase 1 in Vascular Injury of Hypertensive Intracerebral Hemorrhage

This project aims to investigate the role of Lysyl Hydroxylase 1 (LH1) in hypertensive intracerebral hemorrhage (ICH) and its impact on vascular stability. Using a hypertensive ICH mouse model and genetic or viral approaches to modulate LH1 expression, we evaluated how LH1 influences vascular fragility and susceptibility to hemorrhage. Our findings show that reduced LH1 expression is associated with impaired vascular stability, whereas increasing LH1 levels helps reduce the incidence of intracerebral hemorrhage and alleviates hemorrhagic injury. Mechanistic analyses suggest that LH1 may protect the vasculature by maintaining basement membrane structure, regulating matrix related pathways, and suppressing vascular inflammation and cell damage. This study identifies LH1 as a key regulator of vascular stability in hypertensive ICH and highlights its potential therapeutic value.