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HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [RNA-Seq]

ChEBI2015-02-13 更新2026-07-21 收录

RNA剪接调控

B细胞免疫应答

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62129 数据链接链接失效反馈

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HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [RNA-Seq]

应用场景：

创建时间：

2015-02-13

B细胞免疫应答

基因缺陷模型

Analyze kinetics, cell composition and proliferation of germinal center B cells in wt vs Ung-/- vs Aicda-/- vs Ung-/- Aicda-/- mice after immunization with model antigens.

NIAID Data Ecosystem80

The impact of Prp18p on splicing fidelity and efficiency in budding yeast

剪接保真度

RNA剪接调控

Fidelity of 3´-splice site (3´SS) selection by the spliceosome is critical for proper gene expression but is a daunting task considering the low complexity of the 3´SS consensus YAG. Here we show that

Alliance of Genome Resources40

Structure and Novel Functional Mechanism of Drosophila SNF in Sex-Lethal Splicing

RNA剪接调控

果蝇性别决定

Sans-fille (SNF) is the Drosophila homologue of mammalian general splicing factors U1A and U2B″, and it is essential in Drosophila sex determination. We found that, besides its ability to bind U1 snRN

NIAID Data Ecosystem30

C9ORF72 GGGGCC expanded repeats produce splicing dysregulation which correlates with disease severity in amyotrophic lateral sclerosis [HuEx-1_0-st]

神经退行性分子机制

RNA剪接调控

Objective: An intronic GGGGCC-repeat expansion of C9ORF72 is the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The mechanism of neurodegeneration is u

NIAID Data Ecosystem50

The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation

RNA剪接调控

翻译控制

Recent work has associated point mutations in both zinc fingers (ZnF) of the spliceosome component U2AF35 with malignant transformation. However, surprisingly little is known about the functionality o

NIAID Data Ecosystem30

HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response [RNA-Seq]

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