Genome-wide significant and replicated loci for serum calcium in Europeans.

P values are corrected for inflation using genomic control. Replication criteria: overall genome-wide significance (P<5E-8) and one-sided replication P<0.05. I2 was zero for rs1801725, rs1550532, rs10491003, rs7336933 and rs1570669 (I2P>0.20). For rs780094 and rs7481584, I2 were 0.79 and 0.43 with I2P 0.03 and 0.19, respectively. For these latter SNPs, sample size weighted meta-analysis P values were 2.93E-10 and 2.03E-10, respectively. Chr, chromosome. Effect A1 = beta regression coefficient for allele A1; SE, standard error. *one-sided P values.