Treatment categories and regimens under Revised National TB programme, India.

PTB = Pulmonary Tuberculosis; EPTB = Extrapulmonary Tuberculosis; H = Isoniazid; R = Rifampicin; Z = Pyrazinamide; E = Ethambutol; Km = Kanamicin; Lvx = Levofloxacin; Eto = Ethionamide; Cs = Cycloserine.The number before the letters indicates number of months of treatment; numbers in subscript indicate the number of days per week of doses.*Seriously ill includes patients that have military TB, extensive parenchymal infiltration, co-infection with HIV, cavitary disease. In children, seriously ill sputum smear-negative PTB includes all forms of sputum smear-negative PTB other than primary complex. Seriously ill EP-TB includes TB meningitis (TBM), disseminated TB, TB pericarditis, TB peritonitis and intestinal TB, bilateral extensive pleurisy, spinal TB with or without neurological complications, genitourinary TB, and bone and joint TB.**Not seriously ill sputum smear-negative PTB includes primary complex. Not seriously ill EP-TB includes lymph node TB and unilateral pleural effusion.***The dosage strengths are as follows: H : Isoniazid (600 mg), R:Rifampicin (450 mg), Z: Pyrazinamide (1500 mg); E: Ethambutol (1200 mg); S: Streptomycin (750 mg).****MDR-TB diagnosis is done through culture and drug sensitivity testing from a quality-assured laboratory. Treatment of MDR-TB uses a standardized regimen, comprising of 6 drugs – Km (Kanamycin), Lvx (levofloxacin), Eto (Ethionamide), Z (pyrazinamide), E (Ethambutol) and Cs (Cycloserine) during 6–9 months of intensive phase and 4 drugs (Lvx, Eto, E and Cs) during the 18 months of continuation phase. Dosages of drugs are based on three weight bands (16–25 kg, 26–45 Kg, and >45 Kg).