Procyanidin Capsules Relieve Inflammation in Hypertriglyceridemic Acute Pancreatitis via Regulating Oxidative Phosphorylation Signaling

Hypertriglyceridemic acute pancreatitis (HAP) is characterized by mitochondrial oxidative phosphorylation (OXPHOS) impairment and excessive reactive oxygen species (ROS), leading to severe inflammation and organ damage. Existing therapies often lack targeted antioxidant efficacy and long-term stability. In this study, we innovatively designed and synthesized procyanidin capsules using a one-step calcium carbonate template method, which enables sustained release of procyanidin for over one month and exhibits exceptional scavenging capacity for both ROS and RNS. The capsules demonstrated high biocompatibility in macrophage and dendritic cell lines and significantly reduced inflammatory cytokines and pancreatic damage in a HAP mouse model. Proteomic analysis revealed that the therapeutic effect is mediated through the restoration of the aqueous OXPHOS function. This work provides a novel, biocompatible, and potent antioxidant strategy for the targeted treatment of HAP.