Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island

Eight new cembranoids (sarcophytembranoids A–H, 1–8) and 10 known terpenoids (9–18) were obtained from the soft coral Sarcophyton
trocheliophorum of Ximao Island. Notably, 11, 15, and 16 were obtained from a natural
source for the first time. The structures of the new isolates were
elucidated by extensive spectroscopic analysis, optical rotatory dispersion,
and X-ray diffraction experiments. Although the isolated compounds
did not show significant activity against the tested tumor cell lines,
compounds 3, 7, 8, and 10–15 exhibited anti-inflammatory activities
at 10 μM, and compounds 17 and 18 showed
moderate protein tyrosine phosphatase 1B inhibition activities with
the minimum inhibitory concentrations of 22.19 and 11.26 μM,
respectively.