Combined transcriptome and metabolome analysis reveals the regulatory network of histidine kinase QseC in the two-component system of Glaesserella parasuis

Transcriptomic revealed 663 differentially expressed genes (DEGs), including upregulated membrane synthesis genes (plsB and wecA) and downregulated virulence factors (hrpA and pilW). Integrated analysis demonstrated that plsB and wecA formed association networks with methionine and prostaglandin metabolites.