Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist Descriptor: ADENOSINE, Chimera protein of Muscarinic acetylcholine receptor M4 and Adenosine receptor A1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Draper-Joyce, C.J, Danev, R, Thal, D.M, Christopoulos, A, Glukhova, A. Deposit date: 2021-01-12 Release date: 2021-09-08 Last modified: 2025-03-12 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Positive allosteric mechanisms of adenosine A 1 receptor-mediated analgesia. Nature, 597, 2021与内源性激动剂结合的人腺苷A1受体-Gi2蛋白复合物的冷冻电镜（Cryo-EM）结构 标识符：腺苷（adenosine） 毒蕈碱型乙酰胆碱受体M4与腺苷A1受体的嵌合蛋白、鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2…… 作者：Draper-Joyce, C.J.、Danev, R.、Thal, D.M.、Christopoulos, A.、Glukhova, A. 提交日期：2021-01-12；发布日期：2021-09-08；最后修改日期：2025-03-12 研究方法：电子显微镜（分辨率3.3 Å） 引用文献：腺苷A1受体介导镇痛的正向变构调控机制。《自然》（Nature），597卷，2021年