Integrated transcriptomic and metabolomic analysis reveals the regulatory role of Itaconic acid in inflammatory infiltration during myocardial Ischemia-Reperfusion injury

Following establishment of a myocardial ischemia-reperfusion model, tissue samples from the infarct border zone were harvested for transcriptomics and wide-target metabolomic sequencing. Bioinformatics methods were used to analyse the transcriptomics and metabolomics results separately and to perform a joint analysis.